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It was thought that selective cytotoxicity of macrophages could lead to the immunosuppressive effects of CGN

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Conclusions Our data suggested that l-carnitine can mitigate synovitis in FLS and synovial tissue, and the underlying mechanism may be related to improving mitochondrial function and reducing lipid accumulation via the AMPK-ACC-CPT1 signaling pathway

New Safety Signal: Dysesthesia The TRIUMPH-4 Phase 3 trial revealed a previously unreported side effect called dysesthesia, which is an abnormal sensation of touch where normal sensory input feels unusual or uncomfortable

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